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SIRTUINs are NAD-dependent deacetylases implicated in the regulation of metabolism and several aspects of ageing, healthspan and longevity [2-3]

Drugs that reduce hepatic blood flow (e.g., propranolol, a -blocker) can decrease their own clearance

This synergistic effect amplifies its therapeutic potential

Heterozygous mutations in JAK2 (same amino acid V617F) result in essential thrombocythemia or chronic platelet leukemia (megakaryocytes are more sensitive to JAK2 than erythroid cells)

Tranexamic Acid (TXA) is a particular version of the amino acid Lysine, which works within the skin to prevent melanocytes from fully forming new melanin

ISCIENCE 2021, 24(10):103108